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Epigenetic germline inheritance of diet-induced obesity and insulin resistance
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Scritto da Nature Genetics |
 Johannes Beckers, Martin Hrab? de Angelis and colleagues use in vitro fertilization to demonstrate epigenetic germline inheritance of acquired metabolic disorders in mice. They show that a parental high-fat diet renders offspring more susceptible to ... ...
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Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer
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Scritto da Nature Genetics |
 Hidewaki Nakagawa and colleagues report a comprehensive genome-wide mutational landscape of 300 liver cancers from Japanese individuals. They identify candidate driver mutations, including ones in noncoding regions, and structural mutations affecting ... ...
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Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci
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Scritto da Nature Genetics |
 David Ellinghaus and colleagues report a combined association analysis of five chronic inflammatory diseases. They identify 27 new associations and highlight disease-specific association patterns at shared susceptibility loci. ... ...
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Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes
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Scritto da Nature Genetics |
 Adrian Liston and colleagues use a transgenic mouse model to demonstrate that beta cell failure is a mechanistic commonality in type 1 and type 2 diabetes. They find that the changes in the molecular pathways identified as contributing to beta cell l ... ...
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Transcriptomic and epigenomic characterization of the developing bat wing
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Scritto da Nature Genetics |
 Nadav Ahituv, Nicola Illing, Jeff Wall and colleagues sequence the genome of the bat Miniopterus natalensis and perform RNA-seq and ChIP-seq (H3K27ac and H3K27me3) analyses on its developing forelimb and hindlimb autopods at sequential embryonic stag ... ...
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Genetic lineage tracing identifies endocardial origin of liver vasculature
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Scritto da Nature Genetics |
 Bin Zhou and colleagues use genetic labeling in mice to show that endocardial cells of the sinus venosus substantially contribute to the liver vasculature, which thus shares a common developmental origin with coronary arteries. Inhibition of endocard ... ...
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Genomic and functional analyses of Mycobacterium tuberculosis strains implicate ald in D-cycloserine resistance
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Scritto da Nature Genetics |
 Alexander Pym, Ashlee Earl and colleagues use the whole-genome sequences from 498 strains of Mycobacterium tuberculosis to identify new genotypes conferring resistance to antitubercular drugs. They find that loss-of-function mutations in ald (Rv2780) ... ...
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