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Ginecologica
The effect of sperm DNA fragmentation on miscarriage rates: a systematic review and meta-analysis
Scritto da Human Reproduction - current issue   
GinecologicaSTUDY QUESTION

Is there an association between high levels of sperm DNA damage and miscarriage?

SUMMARY ANSWER

Miscarriage rates are positively correlated with sperm DNA damage levels.

 
The association between sperm sex chromosome disomy and semen concentration, motility and morphology
Scritto da Human Reproduction - current issue   
GinecologicaSTUDY QUESTION

Is there an association between sex chromosome disomy and semen concentration, motility and morphology?

SUMMARY ANSWER

Higher rates of XY disomy were associated with a significant increase ... ...

 
Sperm vacuoles are linked to capacitation and acrosomal status
Scritto da Human Reproduction - current issue   
GinecologicaSTUDY QUESTION

Is the presence of nuclear vacuoles really a negative parameter?

SUMMARY ANSWER

As sperm vacuoles are associated with acrosomal and capacitation status, they appear to be a reflection of no ... ...

 
Pravastatin does not prevent antiphospholipid antibody-mediated changes in human first trimester trophoblast function
Scritto da Human Reproduction - current issue   
GinecologicaSTUDY QUESTION

What is the effect of pravastatin on antiphospholipid antibody (aPL) modulation of human first trimester trophoblast function?

SUMMARY ANSWER

Pravastatin does not prevent the effects of aPL ... ...

 
Soluble TRAIL is elevated in recurrent miscarriage and inhibits the in vitro adhesion and migration of HTR8 trophoblastic cells
Scritto da Human Reproduction - current issue   
GinecologicaSTUDY QUESTION

What is the potential physiopathological role of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) in recurrent miscarriage (RM), characterized by at least three consecutive pregnancy losses.

... ...
 
Methylation profile of the promoters of Nanog and Oct4 in ICSI human embryos
Scritto da Human Reproduction - current issue   
GinecologicaSTUDY QUESTION

What is the methylation status of the Nanog and Oct4 promoters in human gametes and ICSI embryos and is abnormal reprogramming of their methylation associated with developmental failure of ICSI embryos?

 
Discovery of phosphatidylcholines and sphingomyelins as biomarkers for ovarian endometriosis
Scritto da Human Reproduction - current issue   
GinecologicaBACKGROUND

Current non-invasive diagnostic methods for endometriosis lack sensitivity and specificity. In search for new diagnostic biomarkers for ovarian endometriosis, we used a hypothesis-generating targeted metabolomics approach ... ...

 
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