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Clinicopathological correlates of adrenal Cushing's syndrome
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Scritto da Journal of Clinical Pathology |
Endogenous Cushing's syndrome is a rare endocrine disorder that incurs significant cardiovascular morbidity and mortality, due to glucocorticoid excess. It comprises adrenal (20%) and non-adrenal (80%) aetiologies. While the majority of cases ar ... ...
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Cell cycle marker expression in benign and malignant intraductal papillary lesions of the breast
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Scritto da Journal of Clinical Pathology |
 Aims
The diagnosis of intraductal papillary lesions of the breast on core biopsy remains challenging in pathology, with most patients requiring formal surgical excision for a definitive diagnosis. The aim of this study was to determ ... ...
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Quantification of histochemical stains using whole slide imaging: development of a method and demonstration of its usefulness in laboratory quality control
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Scritto da Journal of Clinical Pathology |
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Histochemical staining of tissue is a fundamental technique in tissue diagnosis and research, but it suffers from significant variability. Efforts to address this include laboratory quality controls and quality assurance scheme ... ...
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CD1d expression in renal cell carcinoma is associated with higher relapse rates, poorer cancer-specific and overall survival
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Scritto da Journal of Clinical Pathology |
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We hypothesised that CD1d expression in renal cell carcinoma (RCC) may play a role in modifying the host immune response. Our aims were to investigate the expression of CD1d and to correlate this with histopathology and clinica ... ...
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Physical and methylation status of human papillomavirus 16 in asymptomatic cervical infections changes with malignant transformation
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Scritto da Journal of Clinical Pathology |
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To evaluate how the genetic and epigenetic profile of human papillomavirus 16 (HPV16) changes from asymptomatic cervical infections to cervical cancer (CaCx) development. Methods
HPV16 physical statu ... ...
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Mutation detection in formalin-fixed prostate cancer biopsies taken at the time of diagnosis using next-generation DNA sequencing
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Scritto da Journal of Clinical Pathology |
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Assessing whether next-generation DNA sequencing (NGS) can be used to screen prostate cancer for multiple gene alterations in men routinely diagnosed with this disease and/or who are entered into clinical trials. Previous studi ... ...
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Improved detection of hereditary haemochromatosis
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Scritto da Journal of Clinical Pathology |
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There is high prevalence of hereditary haemochromatosis (HH) in North European populations, yet the diagnosis is often delayed or missed in primary care. Primary care physicians frequently request serum ferritin (SF) estimation ... ...
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