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Epigenetic modulators, modifiers and mediators in cancer aetiology and progression
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Scritto da Nature Reviews: Genetics |
 This year is the tenth anniversary of the publication in this journal of a model suggesting the existence of 'tumour progenitor genes'. These genes are epigenetically disrupted at the earliest stages of malignancies, even before mutations, and thus ... ...
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Defining and improving the genome-wide specificities of CRISPR Cas9 nucleases
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Scritto da Nature Reviews: Genetics |
 CRISPR?Cas9 RNA-guided nucleases are a transformative technology for biology, genetics and medicine owing to the simplicity with which they can be programmed to cleave specific DNA target sites in living cells and organisms. However, to translate the ... ...
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Stem cells may help pinpoint patient-specific painkiller
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Scritto da Stem Cell Research News From Medical News Today |
 Researchers have created patient-specific, in vitro models of an extreme pain disorder using neurons generated from the patients' stem cells. ... ...
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Micro heart muscle created from stem cells
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Scritto da Stem Cell Research News From Medical News Today |
 New technique offers cheaper, faster method to create heart tissue for testing drugs and modeling disease. ... ...
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Brain stem cell quiescence needs to be actively maintained in Drosophila
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Scritto da Stem Cell Research News From Medical News Today |
 Hippo signaling pathway regulates quiescence in the neural stem cells of Drosophila larvae. ... ...
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Unchecked mitochondrial DNA mutations could be a problem for stem cell therapies
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Scritto da Stem Cell Research News From Medical News Today |
 Mutations accumulate in human mitochondrial DNA with age, reports a study published April 14 in Cell Stem Cell. ... ...
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Insulin-producing cells grown in lab control glucose spikes in diabetic mice
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Scritto da Stem Cell Research News From Medical News Today |
 Researchers have found a switch that spurs beta cells made from human stem cells to mature to a state where they release insulin in response to glucose spikes. ... ...
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