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Biochimica del cervello

Epigenetic germline inheritance of diet-induced obesity and insulin resistance
Scritto da Nature Genetics   
BiochimicaJohannes Beckers, Martin Hrab? de Angelis and colleagues use in vitro fertilization to demonstrate epigenetic germline inheritance of acquired metabolic disorders in mice. They show that a parental high-fat diet renders offspring more susceptible to ... ...
Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer
Scritto da Nature Genetics   
BiochimicaHidewaki Nakagawa and colleagues report a comprehensive genome-wide mutational landscape of 300 liver cancers from Japanese individuals. They identify candidate driver mutations, including ones in noncoding regions, and structural mutations affecting ... ...
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci
Scritto da Nature Genetics   
BiochimicaDavid Ellinghaus and colleagues report a combined association analysis of five chronic inflammatory diseases. They identify 27 new associations and highlight disease-specific association patterns at shared susceptibility loci. ... ...
Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes
Scritto da Nature Genetics   
BiochimicaAdrian Liston and colleagues use a transgenic mouse model to demonstrate that beta cell failure is a mechanistic commonality in type 1 and type 2 diabetes. They find that the changes in the molecular pathways identified as contributing to beta cell l ... ...
Transcriptomic and epigenomic characterization of the developing bat wing
Scritto da Nature Genetics   
BiochimicaNadav Ahituv, Nicola Illing, Jeff Wall and colleagues sequence the genome of the bat Miniopterus natalensis and perform RNA-seq and ChIP-seq (H3K27ac and H3K27me3) analyses on its developing forelimb and hindlimb autopods at sequential embryonic stag ... ...
Genetic lineage tracing identifies endocardial origin of liver vasculature
Scritto da Nature Genetics   
BiochimicaBin Zhou and colleagues use genetic labeling in mice to show that endocardial cells of the sinus venosus substantially contribute to the liver vasculature, which thus shares a common developmental origin with coronary arteries. Inhibition of endocard ... ...
Genomic and functional analyses of Mycobacterium tuberculosis strains implicate ald in D-cycloserine resistance
Scritto da Nature Genetics   
BiochimicaAlexander Pym, Ashlee Earl and colleagues use the whole-genome sequences from 498 strains of Mycobacterium tuberculosis to identify new genotypes conferring resistance to antitubercular drugs. They find that loss-of-function mutations in ald (Rv2780) ... ...
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