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Biochimica
Epigenetic inheritance of telomere length obscures identification of causative PARN locus
Scritto da Journal of Medical Genetics current issue   
Biochimica

Mean leucocyte telomere length (LTL) has been associated with cancer and several age-associated diseases. Common variants within or near genes known to be involved in telomere biology (TERT, TERC, RTEL1) have been associated with mea ... ...

 
Regulatory networks in evolution
Scritto da Nature Genetics   
BiochimicaComparison of evolutionary adaptations and innovations illuminates the genetic basis for the development of animal forms. Gene networks that retain similar wiring diagrams in diverse and distantly related organisms point to the ways in which regulato ... ...
 
Intolerable secretion and diabetes in tolerant transgenic mice, revisited
Scritto da Nature Genetics   
BiochimicaA new mouse model linking diabetes, insulin secretion and autoimmunity with a high-fat diet supports a shared mechanism for type 1 (T1D) and type 2 (T2D) diabetes. In this model, the protein secretion system of insulin-producing pancreatic beta cells ... ...
 
Fat eggs shape offspring health
Scritto da Nature Genetics   
BiochimicaHow maternal diet influences offspring metabolism is unclear, as it is difficult to distinguish between the effects of the in utero environment and epigenetic factors contributed by the oocyte. In a mouse model of high-fat diet, a new study teases ap ... ...
 
Connecting the regulatory genome
Scritto da Nature Genetics   
BiochimicaDetermining how the evolving genome-wide map of distal regulatory elements is connected with target genes has remained a significant challenge, despite progress in understanding chromatin architecture and regulation. A new study presents a computatio ... ...
 
Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets
Scritto da Nature Genetics   
BiochimicaJian Yang and colleagues propose a method that integrates summary data from GWAS and eQTL studies to identify genes whose expression levels are associated with complex traits because of pleiotropy. They apply the method to five human complex traits a ... ...
 
Enhancer promoter interactions are encoded by complex genomic signatures on looping chromatin
Scritto da Nature Genetics   
BiochimicaSean Whalen and colleagues present a computational method, TargetFinder, for reconstructing three-dimensional regulatory landscapes using one-dimensional genomic features. TargetFinder identifies the minimal set of features necessary to predict indiv ... ...
 
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