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Next generation of small molecules in inflammatory bowel disease
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Scritto da Gut current issue |
 Introduction
Inflammatory bowel disease (IBD) encompasses two major entities: ulcerative colitis (UC) and Crohn's disease (CD).1 Both are chronic, progressive, disabling co ... ...
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Prognostic RNAs in oesophageal squamous cell carcinoma: small is beautiful
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Scritto da Gut current issue |
Oesophageal cancer is a deadly malignancy and is highly heterogeneous at the histological, geographical and molecular levels. It is broadly divided into adenocarcinomas and oesophageal squamous cell carcinomas (OSCCs). OSCCs are particularly prev ... ...
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NEMO--CXCL12/CXCR4 axis: a novel vantage point for antifibrotic therapies in chronic pancreatitis
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Scritto da Gut current issue |
Chronic pancreatitis (CP) is a common GI disorder with an incidence of 4/100 000 and a prevalence of 41/100 000.1 Owing to the chronic nature of the disease, patients wi ... ...
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Non-alcoholic fatty liver disease as driving force in coronary heart disease
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Scritto da Gut current issue |
Non-alcoholic fatty liver disease (NAFLD) has emerged as an imperative public health problem worldwide. NAFLD is now the most common chronic liver disease in high-income countries, and is estimated to affect at least 25%–30% of the general ... ...
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Integrated genomic analysis of recurrence-associated small non-coding RNAs in oesophageal cancer
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Scritto da Gut current issue |
 Objective
Oesophageal squamous cell carcinoma (ESCC) is a heterogeneous disease with variable outcomes that are challenging to predict. A better understanding of the biology of ESCC recurrence is needed to improve patient care. Our ... ...
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TGR5 contributes to glucoregulatory improvements after vertical sleeve gastrectomy in mice
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Scritto da Gut current issue |
 Objective
Vertical sleeve gastrectomy (VSG) produces high rates of type 2 diabetes remission; however, the mechanisms responsible remain incompletely defined. VSG increases circulating bile acid concentrations and bile acid signalli ... ...
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Dual role of Helicobacter and Campylobacter species in IBD: a systematic review and meta-analysis
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Scritto da Gut current issue |
 Objective
To conduct a comprehensive global systematic review and meta-analysis on the association between Helicobacter pylori infection and IBD. As bacterial antigen cross-reactivity has been postulated to be involved in thi ... ...
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