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Allergologia
B cell-T cell interaction: antigen bridge to antigen presentation
AllergologiaGail Bishop describes a 1985 study by Antonio Lanzavecchia that changed our understanding of B cell?T cell interactions. ... ...
 
The unfolded protein response in immunity and inflammation
AllergologiaThe unfolded protein response (UPR) is a highly conserved pathway that allows the cell to manage endoplasmic reticulum (ER) stress that is imposed by the secretory demands associated with environmental forces. In this role, the UPR has increasingly b ... ...
 
Innate sensing of oxidation-specific epitopes in health and disease
AllergologiaAgeing, infections and inflammation result in oxidative stress that can irreversibly damage cellular structures. The oxidative damage of lipids in membranes or lipoproteins is one of these deleterious consequences that not only alters lipid function ... ...
 
Combinatorial antibody libraries: new advances, new immunological insights
AllergologiaImmunochemists have become quite proficient in engineering existing antibody molecules to control their pharmacological properties. However, in terms of generating new antibodies, the combinatorial antibody library has become a central feature of mod ... ...
 
Immune responses and immunopathology in acute and chronic viral hepatitis
AllergologiaHepatitis A virus (HAV), hepatitis B virus (HBV) and hepatitis C virus (HCV) are responsible for most cases of viral hepatitis. Infection by each type of virus results in a different typical natural disease course and clinical outcome that are determ ... ...
 
Immunity by equilibrium
AllergologiaThe classical model of immunity posits that the immune system reacts to pathogens and injury and restores homeostasis. Indeed, a century of research has uncovered the means and mechanisms by which the immune system recognizes danger and regulates its ... ...
 
A novel therapy for genital herpes engages immune cells to provide significant patient benefits for at least a year
AllergologiaA phase II clinical trial demonstrated that a new type of treatment for genital herpes, an immunotherapy called GEN-003, may reduce the activity of the virus and the number of days with recurrent... ... ...
 
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