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Itch inhibits IL-17-mediated colon inflammation and tumorigenesis by ROR- t ubiquitination
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 Dysregulated expression of IL-17 is associated with inflammatory bowel disease. Venuprasad and colleagues show that the ubiquitin ligase Itch negatively regulates the transcription factor ROR-?t to prevent excessive IL-17 production. ... ...
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Immunometabolism: Innate sensing role for metabolic enzyme
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 The glycolytic enzyme hexokinase can act as an innate sensor of bacterial sugars and trigger inflammasome activation. ... ...
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Macrophages: Memories of the dead give strength
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 The uptake of apoptotic corpses generates a molecular memory in macrophages that boosts the innate immune response. ... ...
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Immunometabolism: Mitochondria adapt to bacteria
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 Macrophages adjust their mitochondrial respiratory functions in response to viable bacteria. ... ...
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Infectious diseases: Two-pronged attack on HIV
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 Two studies identify bispecific antibodies that show broad and potent neutralization of HIV in mouse models. ... ...
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Neuroimmunology: Social support from the immune system
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 Interferon-? acts on inhibitory neurons to regulate social behaviour in mice ... ...
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Mucosal immunology: Glial cells support ILC3s and gut defence
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 Production of neurotrophic factors by enteric glial cells controls IL-22 production by ILC3s for barrier defence. ... ...
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