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The transcriptional repressor Hes1 attenuates inflammation by regulating transcription elongation
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 The chemokine CXCL1 serves a critical role in inflammation by mediating the recruitment of neutrophils. Hu and colleagues demonstrate that the transcriptional repressor Hes1 controls CXCL1 via an unusual mechanism that prevents transcription elongati ... ...
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Specialized proteasome subunits have an essential role in the thymic selection of CD8+ T cells
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 Rock and colleagues show that mice that lack all four specialized proteasome ?-subunits and therefore express only constitutive proteasomes in all cells have a profound defect in thymic positive and negative selection. ... ...
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Hydrophobic CDR3 residues promote the development of self-reactive T cells
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 Through analyses of ?-chain variable regions in self-reactive T cell antigen receptors, Huseby and colleagues show that an index based on the interfacial hydrophobicity of amino acids at positions 6 and 7 of the CDR3? segment distinguishes self-react ... ...
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Asynchronous combinatorial action of four regulatory factors activates Bcl11b for T cell commitment
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 Kueh, Rothenberg and colleagues describe distinct, asynchronous and stage-specific mechanisms of T cell commitment mediated by the transcription factors Notch, TCF-1, GATA-3 and Runx1. ... ...
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Human memory T cells with a naive phenotype accumulate with aging and respond to persistent viruses
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 Nikolich-?ugich and colleagues describe a unique subset of human T cells with a naive phenotype and the ability to rapidly produce cytokines in response to engagement of the T cell antigen receptor. ... ...
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Activin A programs the differentiation of human TFH cells
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 Crotty and colleagues identify activin A as a regulator of human TFH cell differentiation. The effects of activin A show evolutionary divergence. ... ...
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CD69 controls the uptake of L-tryptophan through LAT1-CD98 and AhR-dependent secretion of IL-22 in psoriasis
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Sanchez-Madrid and colleagues show that CD69 associates with the amino acid transporter LAT1-CD98 to control the uptake of tryptophan and AhR-dependent secretion of IL-22 by skin ?? T cells. ... ...
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