| Orthostatic tremor: a cerebellar pathology |
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Scritto da Brain - current issue |
See Muthuraman et al. (doi:10.1093/aww164) for a scientific commentary on this article.
Primary orthostatic tremor is characterized by high frequency tremor affecting ... ...
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| Functional correlates of the therapeutic and adverse effects evoked by thalamic stimulation for essential tremor |
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Scritto da Brain - current issue |
Deep brain stimulation is an established neurosurgical therapy for movement disorders including essential tremor and Parkinson’s disease. While typically highly effective, deep brain stimulation can sometimes yield suboptimal therapeutic be ... ...
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| Movement-related dynamics of cortical oscillations in Parkinsons disease and essential tremor |
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Scritto da Brain - current issue |
Recent electrocorticography data have demonstrated excessive coupling of beta-phase to gamma-amplitude in primary motor cortex and that deep brain stimulation facilitates motor improvement by decreasing baseline phase-amplitude coupling. However, ... ...
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| Basal ganglia dysfunction in idiopathic REM sleep behaviour disorder parallels that in early Parkinsons disease |
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Scritto da Brain - current issue |
See Postuma (doi:10.1093/aww131) for a scientific commentary on this article.
Resting state functional magnetic resonance imaging dysfunction within the basal ganglia networ ... ...
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| Atomoxetine restores the response inhibition network in Parkinsons disease |
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Scritto da Brain - current issue |
Parkinson’s disease impairs the inhibition of responses, and whilst impulsivity is mild for some patients, severe impulse control disorders affect ~10% of cases. Based on preclinical models we proposed that noradrenergic denervation contrib ... ...
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| The relationship between cerebrospinal fluid markers of Alzheimer pathology and positron emission tomography tau imaging |
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Scritto da Brain - current issue |
The two primary molecular pathologies in Alzheimer’s disease are amyloid-β plaques and tau-immunoreactive neurofibrillary tangles. Investigations into these pathologies have been restricted to cerebrospinal fluid assays, and positron e ... ...
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| Biomarker clusters are differentially associated with longitudinal cognitive decline in late midlife |
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Scritto da Brain - current issue |
The ability to detect preclinical Alzheimer’s disease is of great importance, as this stage of the Alzheimer’s continuum is believed to provide a key window for intervention and prevention. As Alzheimer’s disease is characterize ... ...
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