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Esame neurologico obiettivo: test delle sensibilità

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Neurologia
Dynamic relationships between age, amyloid-{beta} deposition, and glucose metabolism link to the regional vulnerability to Alzheimers disease
Scritto da Brain - current issue   
Neurologia

See Hansson and Gouras (doi:10.1093/aww146) for a scientific commentary on this article.

Although some brain regions such as precuneus and lateral temporo-parietal cortex ha ... ...

 
Tauopathy induced by low level expression of a human brain-derived tau fragment in mice is rescued by phenylbutyrate
Scritto da Brain - current issue   
Neurologia

Human neurodegenerative tauopathies exhibit pathological tau aggregates in the brain along with diverse clinical features including cognitive and motor dysfunction. Post-translational modifications including phosphorylation, ubiquitination and tr ... ...

 
Neural, electrophysiological and anatomical basis of brain-network variability and its characteristic changes in mental disorders
Scritto da Brain - current issue   
Neurologia

See Mattar et al. (doi:10.1093/aww151) for a scientific commentary on this article.

Functional brain networks demonstrate significant temporal variability and dynamic ... ...

 
Thalamic pathology and memory loss in early Alzheimers disease: moving the focus from the medial temporal lobe to Papez circuit
Scritto da Brain - recent issues   
Neurologia

It is widely assumed that incipient protein pathology in the medial temporal lobe instigates the loss of episodic memory in Alzheimer’s disease, one of the earliest cognitive deficits in this type of dementia. Within this region, the hippoc ... ...

 
Microvascular alterations and the role of complement in dermatomyositis
Scritto da Brain - recent issues   
Neurologia

Different mechanisms have been proposed to explain the pathological basis of perifascicular muscle fibre atrophy in dermatomyositis. These include ischaemia due to immune-mediated microvascular injury, enhanced expression of type 1 interferon-ind ... ...

 
Genetic and phenotypic characterization of complex hereditary spastic paraplegia
Scritto da Brain - recent issues   
Neurologia

The hereditary spastic paraplegias are a heterogeneous group of degenerative disorders that are clinically classified as either pure with predominant lower limb spasticity, or complex where spastic paraplegia is complicated with additional neurol ... ...

 
Sodium selenate retards epileptogenesis in acquired epilepsy models reversing changes in protein phosphatase 2A and hyperphosphorylated tau
Scritto da Brain - recent issues   
Neurologia

There are no treatments in clinical practice known to mitigate the neurobiological processes that convert a healthy brain into an epileptic one, a phenomenon known as epileptogenesis. Downregulation of protein phosphatase 2A, a protein that cause ... ...

 
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