FCE News https://fcenews.it/index.php?option=com_content&view=category&id=1000&layout=blog&Itemid=123 Fri, 24 Jun 2016 13:40:38 +0000 Joomla! 1.5 - Open Source Content Management it-it Clinical development of cancer therapeutics that target metabolism https://fcenews.it/index.php?option=com_content&view=article&id=210547:clinical-development-cancer-therapeutics&catid=1000:interna&Itemid=123 https://fcenews.it/index.php?option=com_content&view=article&id=210547:clinical-development-cancer-therapeutics&catid=1000:interna&Itemid=123

Glucose and glutamine metabolism in cancer cells are markedly elevated relative to non-transformed normal cells. This metabolic reprogramming enables the production of adenosine triphosphate and the anabolic precursors needed for survival, growth ... ...]]> [email protected] (QJM) Interna Tue, 21 Jun 2016 08:00:00 +0000

Prognostic significance of anaemia in patients with heart failure with preserved and reduced ejection fraction: results from the MAGGIC individual patient data meta-analysis https://fcenews.it/index.php?option=com_content&view=article&id=210548:prognostic-significance-anaemia-patients&catid=1000:interna&Itemid=123 https://fcenews.it/index.php?option=com_content&view=article&id=210548:prognostic-significance-anaemia-patients&catid=1000:interna&Itemid=123

Background: Anaemia is common among patients with heart failure (HF) and is an important prognostic marker.

Aim: We sought to determine the prognostic importance of anaemia in a large multinational pooled dataset of prospecti ... ...]]> [email protected] (QJM) Interna Tue, 21 Jun 2016 08:00:00 +0000

Do traditional risk stratification models for cerebrovascular events apply in irradiated head and neck cancer patients https://fcenews.it/index.php?option=com_content&view=article&id=210549:traditional-risk-stratification-models&catid=1000:interna&Itemid=123 https://fcenews.it/index.php?option=com_content&view=article&id=210549:traditional-risk-stratification-models&catid=1000:interna&Itemid=123

Background: Primary radical radiotherapy (RT) for head and neck cancer (HNC) often results in significant radiation dose to the carotid arteries.

Aim: We assessed whether HNC patients are at increased risk of a cerebrovascula ... ...]]> [email protected] (QJM) Interna Tue, 21 Jun 2016 08:00:00 +0000

Attitudes to outcomes measured in clinical trials of cardiovascular prevention https://fcenews.it/index.php?option=com_content&view=article&id=210550:attitudes-outcomes-measured-clinical&catid=1000:interna&Itemid=123 https://fcenews.it/index.php?option=com_content&view=article&id=210550:attitudes-outcomes-measured-clinical&catid=1000:interna&Itemid=123

Background: Selecting outcome measures in cardiovascular prevention trials should be informed by their importance to selected populations. Major vascular event outcomes are usually prioritized in these trials with considerably less attenti ... ...]]> [email protected] (QJM) Interna Tue, 21 Jun 2016 08:00:00 +0000

Association of HaeIII single nucleotide polymorphisms in the SLC2A1 gene with risk of diabetic nephropathy; evidence from Kurdish patients with type 2 diabetes mellitus https://fcenews.it/index.php?option=com_content&view=article&id=210551:association-haeiii-single-nucleotide&catid=1000:interna&Itemid=123 https://fcenews.it/index.php?option=com_content&view=article&id=210551:association-haeiii-single-nucleotide&catid=1000:interna&Itemid=123

Aims: Given the growing rate of patients with type 2 diabetes mellitus, uncovering the effects of gene polymorphism on diabetes pathogenesis has attracted a lot of attention. Because glucose transporter 1 is involved in glucose uptake, the ... ...]]> [email protected] (QJM) Interna Tue, 21 Jun 2016 08:00:00 +0000

Epidemiology of adolescent substance use in London schools https://fcenews.it/index.php?option=com_content&view=article&id=210552:epidemiology-adolescent-substance-london&catid=1000:interna&Itemid=123 https://fcenews.it/index.php?option=com_content&view=article&id=210552:epidemiology-adolescent-substance-london&catid=1000:interna&Itemid=123

Background: Alcohol and substance use in adolescence can be associated with a range of health, emotional, social, behavioural and legal problems. There has been a change in the recreational drugs available to users in recent years; however ... ...]]> [email protected] (QJM) Interna Tue, 21 Jun 2016 08:00:00 +0000

Circulating DNA in solid organ cancers--analysis and clinical application https://fcenews.it/index.php?option=com_content&view=article&id=208018:circulating-solid-organ-cancers&catid=1000:interna&Itemid=123 https://fcenews.it/index.php?option=com_content&view=article&id=208018:circulating-solid-organ-cancers&catid=1000:interna&Itemid=123

Circulating tumour DNA (ctDNA) is that fraction of circulating DNA that is derived from a patient’s cancer. For a number of years, patients with haematological malignancies have had their disease diagnosed or monitored using tests based on ... ...]]> [email protected] (QJM) Interna Wed, 27 Apr 2016 08:00:00 +0000

The duration of the orthostatic blood pressure drop is predictive of death https://fcenews.it/index.php?option=com_content&view=article&id=208019:duration-orthostatic-blood-pressure&catid=1000:interna&Itemid=123 https://fcenews.it/index.php?option=com_content&view=article&id=208019:duration-orthostatic-blood-pressure&catid=1000:interna&Itemid=123

Background: Orthostatic hypotension (OH) affects 6% of community-dwelling older people. This increases to 60% when non-invasive, continuous blood pressure (BP) monitoring is used, due to identification of transient drops in BP which recove ... ...]]> [email protected] (QJM) Interna Wed, 27 Apr 2016 08:00:00 +0000

Expression of Na+-K+-2Cl- cotransporter isoform 1 (NKCC1) predicts poor prognosis in lung adenocarcinoma and EGFR-mutated adenocarcinoma patients https://fcenews.it/index.php?option=com_content&view=article&id=208020:expression-cotransporter-isoform-nkcc1&catid=1000:interna&Itemid=123 https://fcenews.it/index.php?option=com_content&view=article&id=208020:expression-cotransporter-isoform-nkcc1&catid=1000:interna&Itemid=123

Background: Sodium–potassium-chloride cotransporter isoform 1 (NKCC1) is an active ions cotransporter and modulates cellular volume and migration. NKCC1 blockers can inhibit cancer cell growth.

Aim: We aimed to elucidat ... ...]]> [email protected] (QJM) Interna Wed, 27 Apr 2016 08:00:00 +0000

Readmissions of medical patients: an external validation of two existing prediction scores https://fcenews.it/index.php?option=com_content&view=article&id=208021:readmissions-medical-patients-external&catid=1000:interna&Itemid=123 https://fcenews.it/index.php?option=com_content&view=article&id=208021:readmissions-medical-patients-external&catid=1000:interna&Itemid=123

Background: Hospital readmissions are increasingly used as a quality indicator with a belief that they are a marker of poor care and have led to financial penalties in UK and USA. Risk scoring systems, such as LACE and HOSPITAL, have been ... ...]]> [email protected] (QJM) Interna Wed, 27 Apr 2016 08:00:00 +0000